ABSTRACT
Objective To observe the effect of sterimar physiological sea water spray nasal spray on children with mild intermittent allergic rhinitis (AR).Methods 81 cases with mild intermittent AR from March 2014 to March 2015.All the cases were divided into observation group (n=40) and control group (n=41) according to the double blind and random number table method.The control group were given conventional loratadine treatment, observation group on the basis of the control group given sterimar physiological sea water spray nasal spray treatment.The symptoms of allergic rhinitis, signs score, mucociliary transport rate and clinical curative effect between two groups pre-and post-treatment were analysed and compared.Results After treatment, the symptoms of allergic rhinitis, signs score in observation group were significantly lower than those in control group (t=12.908,t=11.340;P<0.05).The mucociliary transport rate in observation group was significantly higher than that in control group (t =4.119;P<0.05).The total effective rate of observation group was significantly higher than that of control group (97.50%vs.80.49%;χ2 =5.933,P<0.05).Conclusion The clinical treatment effect of sterimar physiological sea water spray nasal spray could effectively alleviate the symptoms in the treatment of children with mild intermittent AR, which has an accurate efficacy.
ABSTRACT
Objective:To study the clinical effect and safety of aerosol inhalation of recombinant human interferon α-2b( P. puti-da) in the children with viral upper respiratory tract infection ( VURI) . Methods: Totally 100 children diagnosed as viral upper re-spiratory tract infection were randomly divided into the observation group and the control group with 50 cases in each. The two groups of children were both given symptomatic and supportive treatment, and the observation group was given IFN-α2b (P. putida) 150 000 IU·kg-1 ·d-1 in 2-4 ml 0. 9% sodium chloride injection with aerosol inhalation, qd, 5-10 min each time, and the control group was given ribavirin 10-15 mg·kg-1 ·d-1 in 5% glucose injection 150 ml, ivd, and a course of treatment was continuous 5 d. The fever, cold symptoms ( catarrh, cough, malaise) and clinical efficiency of the two groups were compared. Results:The defervescence effect of the observation group was significantly higher than that of the control group after the treatment(P<0. 05). The effect in the children with mild and moderate cough in the observation group was better than that in the control group, and the changes were statistically sig-nificant difference(P<0. 01). The heat range, cough fading time, catarrh symptom and systemic symptom disappearance time in the observation group were significantly better than those in the control group(P<0. 05). The clinical efficient rate of the observation group was 96. 0%, which was significantly higher than that (84. 0%) in the control group(P<0. 05) . Conclusion: Combined with the conventional therapy, aerosol inhalation of IFN-α2b can be effectively and safely used for treating viral upper respiratory tract infec-tion in children, which is worthy of popularized use in clinics.